Q1: MicroRNAs have been implicated in the pathophysiology of a range of psychiatric disorders such as schizophrenia and depression.

Q1: MicroRNAs have been implicated in the pathophysiology of a range of psychiatric disorders such as schizophrenia and depression. This has led to the suggestion that microRNAs themselves could be drug targets that could be exploited for the treatment of these disorders. Describe some of the challenges that need to be overcome in developing microRNA based therapeutics. (2 pages)Q2: A- Discuss the options that are available to produce genome modifications in the mouse using mouse embryonic stem …

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